Reflecting a decade's worth of changes, this Second Edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them.

The book presents a historical review of the use of animal models used in toxicology and an overview of broad considerations of metabolism and its relevance.

Chapters covering the eight major species used in toxicology and experimental biology form the core of the book. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provide an excellent introductory course along with guidance to the literature for more detailed understanding.

Features:

• provides tables of normative physiology, pathology, reproductive, clinical laboratory, and metabolism data
• presents detailed discussions of husbandry, major diseases, and handling for the major species used in toxicology and experimental biology
• contains detailed descriptions and illustrations for dosing, blood collection, and other procedures
• reviews current laws and regulations governing animal care and use in major countries
• includes extensive appendices of acronyms, regulatory and scientific Web sites, animal suppliers, and a lexicon of terms used in describing clinical signs