1. The History of Epstein–Barr Virus
- References
2. Virology and Molecular Biology of Epstein–Barr Virus
- Introduction
- Virus Structure and Genome
- Virus Replication
- Latent Infection
- Lytic Infection
- Conclusions
- References
3. Epidemiology of Primary Epstein–Barr Virus Infection and Infectious Mononucleosis
- Introduction
- Sources of Epidemiologic Data
- Descriptive Epidemiology
- References
4. Pathology of Primary and Persistent Epstein–Barr Virus Infection
- Introduction
- Infectious Mononucleosis
- Persistent EBV Infection
- EBV Replication in Primary and Persistent Infection
- Fatal IM, CAEBV Infection, and EBV-AHS
- Expression of Cytokine and Chemokine Genes in IM and CAEBV Infection
- Conclusions
- References
5. The Immune Response to Epstein–Barr Virus
- Introduction
- Humoral Response
- T-Cell Response During IM and After Resolution of Disease
- T-Cell Response in Asymptomatic Primary Infection
- T-Cell Response in Healthy Virus Carriers
- T-Cell–Mediated Control of EBV-Associated Tumors
- TCR Selection
- Concluding Remarks and Future Directions
- References
6. Clinical Features of Infectious Mononucleosis
- Clinical Characterization of Acute Infectious Mononucleosis
- Atypical Presentations of Acute IM
- Acute Complications of EBV IM
- Therapy of Acute Infection
- Conclusions
- References
7. Epstein-Barr Virus Disease-Serologic and Virologic Diagnosis
- Introduction
- Heterophile Antibodies
- Conventional EBV Serologic Tests
- Determining EBV Status Based on Serological Panels
- Detection of EBV by Viral Culture
- Detection of EBV Genome
- Direct Detection of Latent EBV Infection
- Use of EBV Diagnostic Tests in Selected Clinical Circumstances
- References
8. Epstein–Barr Virus and the Nervous System
- EBV-Related Neurological Diseases
- Treatment
- Relation Between EBV and MS
- Conclusion
- References
9. Epstein–Barr Virus and HIV
- Introduction
- HIV Infection, EBV Antibody Responses, and EBV Copy Number
- Viral Strains in HIV-Infected Patients
- Non-Neoplastic Manifestations of EBV Infection in HIV-Infected Patients
- HIV and Lymphoma
- HIV and Other Malignancies
- EBV Detection and Clinical Decision Making
- Prevention of EBV-Associated Lymphoma
- Treatment of EBV-Associated Lymphoma
- Conclusion
- References
10. Burkitt Lymphoma
- Introduction
- Classification and Characteristics of BL
- Infectious Cofactors
- Molecular Pathogenesis of BL
- EBV in BL—Causal Role or B-Cell Cohabitation?
- Prospects for Future Discovery
- Further Reading
- References
11. Epstein–Barr Virus Infection in Hodgkin Lymphomas
- Introduction
- Histology of HL
- Biology of HRS Cells
- EBV DNA and RNA in HLs
- EBV Antigen Expression in HLS
- EBV Infection and the Phenotype of HRS Cells
- HL and EBV-Specific Immunity
- Conclusions
- References
12. Posttransplant Lymphoproliferative Disorder
- Introduction
- Epidemiology
- Pathology of PTLD
- Clinical Features and Management
- Early Diagnosis and Screening
- References
13. T-Cell Lymphomas Associated with Epstein–Barr Virus
- Introduction
- Types of T-Cell Lymphomas and Their Association with EBV
- Future Considerations
- References
14. Nasopharyngeal Carcinoma
- Introduction
- EBV Gene Expression During Latent Infection
- Genetic Susceptibility of NPC
- Association of EBV Infection with NPC
- Genetic Alterations in NPC
- EBV Infection in Epithelial Cells and B Lymphocytes
- EBV Infection in Nasopharyngeal Epithelial Cells
- Transformation Properties of Gene Products Encoded by EBV
- Proposed Sequence of Events for NPC Development
- References
15. Leiomyosarcoma
- Introduction
- Epidemiology
- Pathogenesis
- Conclusions
- References
16. X-Linked Lymphoproliferative Disease
- The Discovery of the Disease
- The XLP Registry
- The Diagnosis of XLP
- Clinical Manifestations of XLP
- Genotype–Phenotype Correlation
- The Role of EBV Infection in XLP
- Treatment and Prognosis
- The XLP Gene
- The XLP Protein
- XLP Mutations
- Conclusions
- References
17. Diseases Possibly Associated with Epstein–Barr Virus
- Introduction
- Laboratory Detection of EBV Infection
- Methodological Issues and Their Applications
- Clinical Illnesses
- Identification of EBV as a Potential Cause of Autoimmune Disease
- Synthesis
- References
18. Treatment of Epstein–Barr Virus Infections: Chemotherapy, Antiviral Therapy, and Immunotherapy
- Introduction
- Treatment of Diseases Associated with EBV Infection
- Prevention of EBV Infection or EBV-Associated Disease
- Summary
- References
19. The Development of Epstein–Barr Virus Vaccines
- What Is the Demand for EBV Vaccines?
- Progress with Other Human Herpesvirus Vaccines
- Several Alternative Objectives for EBV Vaccination
- GP350 Vaccines
- GP350 Vaccines and a Primate Model of EBV Lymphoma
- Peptide Vaccines
- Other Animal Models
- Human Trials
- Further Considerations in EBV Vaccine Design
- Possible Therapeutic Vaccination
- Conclusions and Future Objectives
- References
- ALEX TSELIS is Associate Professor, Neurology Department, Wayne State University, Detroit, Michigan. He received the M.D. degree from the University of Miami, Florida, and the Ph.D. degree from Brown University, Providence, Rhode Island.
- HAL B. JENSON is Professor of Pediatrics and Dean of the Western Campus of Tufts University School of Medicine, and Chief Academic Officer and Senior Vice President for Academic Affairs at Baystate Health in Springfield, Massachusetts. He received the M.D. degree from George Washington University, Washington, D.C.
"…we should congratulate the editors of this book both for its conception and for assembling a group of internationally recognized experts to review the current state of knowledge of EBV infection…a welcome addition to the bookshelves of any teaching institution or clinical virology laboratory."
Clinical Infectious Diseases
