Introduction
- Chapter Outline
- Historical Aspects
- Types of Toxic Substance
- Types of Exposure
- Dose-Response Relationship
- Summary and Learning Objectives
- Questions
- Bibliography
Disposition of Toxic Compounds
- Chapter Outline
- Absorption of Toxic Compounds
- Distribution of Toxic Compounds
- Excretion of Toxic Compounds
- Summary and Learning Objectives
- Questions
- Bibliography
Metabolism of Foreign Compounds
- Chapter Outline
- Introduction
- Factors Affecting Toxic Responses
- Summary and Learning Objectives
- Questions
- Bibliography
Types of Exposure and Response
- Chapter Outline
- Types of Exposure
- Route of Exposure
- Types of Toxic Exposure
- Biomarkers
- Summary and Learning Objectives
- Questions
- Bibliography
Drugs as Toxic Substances
- Chapter Outline
- Introduction
- Paracetamol
- Aspirin (salicylate)
- Hydralazine
- Halothane
- Debrisoquine
- Thalidomide
- Drug Interactions
- Altered Responsiveness: glucose-6-phosephate dehydrogenase deficiency
- Summary and Learning Objectives
- Questions
- Bibliography
Industrial Toxicology
- Chapter Outline
- Introduction
- Means of Exposure
- Toxic Effects
- Vinyl Chloride
- Cadmium
- Aromatic Amines
- Asbestos
- Legislation
- Summary and Learning Objectives
- Questions
- Bibliography
Food Additives and Contaminants
- Chapter Outline
- Introduction
- Tartrazine
- Saccharin
- Food Contaminants
- Summary and Learning Objectives
- Questions
- Bibliography
Pesticides
- Chapter Outline
- Introduction
- DDT
- Organophosphorus Compounds
- Paraquat
- Fluoroacetate
- Summary and Learning Objectives
- Questions
- Bibliography
Environmental Pollutants
- Chapter Outline
- Introduction
- Air Pollution
- Particulates
- Acid Rain
- Lead Pollution
- Water Pollution
- Arsenic
- Food Chains
- Endocrine Disruptors
- Mercury and Methylmercury
- Summary and Learning Objectives
- Questions
- Bibliography
Natural Products
- Chapter Outline
- Plant Toxins
- Animal Toxins
- Fungal Toxins
- Microbial Toxins
- Summary and Learning Objectives
- Questions
- Bibliography
Household Products
- Chapter Outline
- Introduction
- Carbon Monoxise
- Antifreeze: Ethylene Glycol
- Cyanide
- Alcohol
- Glue Sniffing and Solvent Abuse
- Antidotes and the Treatment of Poisoning
- Summary and Learning Objectives
- Questions
- Bibliography
Toxicity Testing and Risk Assessment
- Chapter Outline
- Introduction
- Evaluation of Toxicity
- Acute Toxicity Tests
- Sub-acute Toxicity Tests
- Chronic Toxicity Tests
- Test in vitro
- Risk Assessment and Interpretation of Toxicological Data
- Conclusions
- Summary and Learning Objectives
- Questions
- Bibliography
