- 1. Introduction: Cancer vaccines: mechanism and a clinical overview
Antoni Ribas and Adrian Bot - 2. Revisiting the paradigm on the putative need for antigen-specific responses in cancer
Gail D. Sckisel, Julia K. Tietze, and William J. Murphy - 3. Development of novel immune interventions for genito-urinary cancers
Neeraj Agarwal and Nicholas J. Vogelzang - 4. Autologous cellular immunotherapy in late-stage prostate cancer: The development history of sipuleucel-T (PROVENGE®)
David L. Urdal and Mark W. Frohlich - 5. Design, development and translation of poxvirus-based vaccines for cancer
Benedetto Farsaci, Anna Kwilas, and James W. Hodge - 6. Of mice and men (and dogs!): The first approved cancer therapy vaccine
Philip J. Bergman and Jedd D. Wolchok - 7. Recombinant protein vaccination for antigen-specific cancer immunotherapy
Pedro de Sousa Alves and Vincent Brichard - 8. Antigen-targeted, synthetic vaccines for metastatic cancer
Zhiyong Qiu, David C. Diamond, Kent A. Smith, Dar Rosario, Sabrina Miles, Mihail Obrocea, Thomas M. Kundig and Adrian Bot - 9. Clinical perspectives in cancer vaccines for hematological diseases
Maurizio Chiriva-Internati, Leonardo Mirandola, Marjorie Jenkins, Martin Cannon, Everardo Cobos, and W. Martin Kast - Epitope-based vaccines for cancer
Vy Phan-Lai, Denise L. Cecil, Gregory E. Holt, Daniel R. Herendeen, Forrest Kievit, Miqin Zhang, and Mary L. Disis - 11. Emerging clinical trial design concepts for therapeutic cancer vaccines
Christina Musselli, Leah Isakov, and Kerry Wentworth - 12. T-cell immune monitoring assays to guide the development of new cancer vaccines
Cedrik M. Britten, Sylvia Janetzki, Cecile Gouttefangeas, Marij J.P. Welters, Michael Kalos, Christian Ottensmeier, Axel Hoos, and Sjoerd H. van der Burg - 13. A biomarker-based, systems biology approach guiding the development of active immunotherapies and immune monitoring
Glenda Canderan, Peter Wilkinson, John Schatzle, Mark Cameron, and Rafick-Pierre Sékaly - 14. Targeting regulatory T cells and other strategies to enable cancer vaccines
Christopher Paustian, Shawn M. Jensen, Sarah Church, Sachin Puri, Chris Twitty, Hong-Ming Hu, Brendan D. Curti, Walter J. Urba, Raj K. Puri and Bernard A. Fox - 15. Molecular targeting of cancer stem cells
Zhenhua Li, Debraj Mukherjee, Jang-Won Lee, and John S. Yu - 16. RNA in cancer vaccine therapy
Smita Nair, David Boczkowski, Scott Pruitt, and Johannes Urban - 17. Induction of innate immunity by nucleic acids: A potential adjuvant for cancer vaccines?
Bo Jin and Anthony E.T. Yeo - 18. Passive immunotherapy by T cell-engaging bispecific antibodies
Patrick A. Baeuerle and Benno Rattel - 19. Antibodies to peptide-HLA complexes have potential application for cancer diagnosis and therapy
Jon A. Weidanz and William H. Hildebrand
VACCINE PLATFORMS FOR GENITO-URINARY CANCERS, WITH POTENTIAL APPLICABILITY TO OTHER TUMORS
VACCINES FOR SOLID CANCERS AND HEMATOLOGICAL MALIGNANCIES
VACCINE DEVELOPMENT: TRIAL DESIGN AND IMMUNE ASSAYS
EMERGING NEW VACCINE STRATEGIES, TARGETS, AND ADJUVANTS
NEXT-GENERATION HYBRID ACTIVE/PASSIVE IMMUNOTHERAPIES
- Adrian Bot, MD, PhD, was a Vice President of Scientific Management at MannKind Corporation, Valencia, California, and recently joined Kite Pharma, Inc. in Los Angeles, California, as Chief Scientific Officer. He was a Guest Scientist at the Scripps Research Institute in La Jolla and Scientist, Principal Scientist and Director of Immunology Research at Alliance Pharmaceutical Corp. in San Diego before joining Allecure Pharmaceuticals, then MannKind Corp as a Director of Research and Development. Dr. Adrian Bot’s background is in theoretical and experimental immunology, cancer research and drug development. He has authored and co‐authored more than 70 peer‐reviewed research articles, reviews, book chapters and monographs, in basic and applied immunology. Dr. Bot holds patents and patent applications on DNA vaccines, microparticle‐based technologies, immune therapeutic approaches and innovative drugs in oncology and autoimmune diseases. He is on several scientific advisory panels, such as the Medical Science Review Committee of the Juvenile Diabetes Research Foundation. Dr. Bot was a former Associate Editor of Journal of Immunology and is the current Editor in Chief of the Informa Healthcare journal International Reviews of Immunology.
- Mihail Obrocea, MD, was Vice President of Clinical Development Oncology at MannKind Corporation, Valencia, California and recentely joined, as senior executive the Abbott Biotherapeutics oncology group in Redwood City, California. Dr. Obrocea received his M.D. from Carol Davila University of Medicine and Pharmacy, Bucharest, Romania and trained in hematology/oncology at Dartmouth Medical School in New Hampshire. He has over 12 years of drug development experience in hematology and oncology including biological agents and cancer vaccines, small molecules and various cytotoxic agents. Dr. Obrocea has published in oncology peer‐reviewed literature and most recently co-edited along with Dr. Bot, Cancer Vaccines: Challenges and Opportunities in Translation. He also holds various patents in the field of biotechnology.
- Francesco Marincola, MD, FACS, is Chief of the Infectious Disease and Immunogenetics Section in the Department of Transfusion Medicine at the Clinical Center of the National Institutes of Health in Bethesda, Maryland. Dr. Marincola serves as the Editor‐in‐Chief, Journal of Translational Medicine; US Senior Editor of Immunotherapy, Associate Editor for The Journal of Immunotherapy and a former Section Editor for Informa Healthcare journal Expert Opinion in Biological Therapy. Dr. Marincola is an author of over 350 peer reviewed research articles and over 100 abstracts. He has been invited to speak at over 200 national and international meetings. Dr. Marincola is the second most cited scientist in melanoma during the last ten years, with 55 papers cited 3,704 times to date. Dr. Marincola’s record includes 63 papers cited a total of 2,955 times to date in the field of Clinical Medicine and 51 papers cited a total of 2,204 times to date in the field of Immunology.

