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Particle Toxicology

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Particle Toxicology

By Ken Donaldson, University of Edinburgh, Scotland and Paul Borm, Zuyd University, Heerlan, The Netherlands

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$200.00
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Book Specifications

  • Available to Purchase
  • Published: December 2006
  • ISBN: 9780849350924
  • First Edition
  • 456 pages
  • Format: Hardcover
  • Size: 7" x 10"
  • 101 Black and White Illustrations
  • 5 Colour Illustrations

Quick Overview

Particle Toxicology integrates the current knowledge in particulate physico-chemistry, cell/molecular biology, and toxicology into a single volume. While using the classical toxicology paradigm of exposure-dose-response, it provides reviews on the mechanisms and properties of pathogenic particles and their pathogenic effects.

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Particle Toxicology integrates the current knowledge in particulate physico-chemistry, cell/molecular biology, and toxicology into a single volume. While using the classical toxicology paradigm of exposure-dose-response, it provides reviews on the mechanisms and properties of pathogenic particles and their pathogenic effects.

The text describes how these actions may be related to specific site of deposition, translocation, particle composition, shape and the outcome of various pathogenic processes involving pro-inflammatory effects and inflammatory signaling, oxidative and nitrosative stress, particulate interactions in the pulmonary, cardiovascular, and central nervous systems, as well as genotoxic effects of ultrafine and other particles.

Features:

  • focuses on mechanistic toxicology of exposure to particles
  • explains adverse health effects using the classic toxicology paradigm of exposure-dose-response
  • focuses on oxidative stress and the inflammatory response as the main paradigm at various sites in the body including the lungs, brain and cardiovascular system
  • includes the structure, mineralogy, and toxicology of nanoparticles as well as industrial particles such as silica, asbestos, and metal dust
  • emphasizes a multidisciplinary approach to understanding particle toxicology through physics, chemistry, environmental, and medical science