Revised to reflect modern pharmaceutical compacting techniques, this Second Edition explores compaction of powder constituents (both active ingredient and excipients) and guides pharmaceutical engineers, formulation scientists, product development and quality assurance personnel through the compaction formulation process to ensure consistent and reproducible disintegration and dispersion profiles. This unique reference describes the physical structure of pharmaceutical compacts, the bonding phenomena that occur during powder compaction, and the compression mechanisms of pharmaceutical particles.
This updated edition continues to cover the theory and basic principles of powder compaction, but now focuses further on its application, indicating the important parameters for success in small batches and how this process can be migrated into commercial manufacture.
KEY FEATURES INCLUDE:
coverage of compaction data analysis techniques to ensure optimal application in manufacture
fundamentals of instrumentation for compaction
compaction functionality testing, which is likely to become a USP requirement
design space for compaction, an essential consideration for quality by design, and PAT
the metrics required for scalability in tablet compression and that act as performance indicators in commercial viability
components of interactive compaction and preformulation database for commonly used excipients to help speed up process considerations and enhance outcomes
