Epidemiology
- Acute exacerbations are major unmet needs in asthma therapy
- Socio-economic costs of acute asthma exacerbations
- Seasonal patterns of asthma exacerbations
- Aetiology of asthma exacerbations in children Aetiology of asthma exacerbations in adults
- Differentiating asthma exacerbations from poor asthma control
- Do frequent exacerbations lead to accelerated long term decline in lung function in asthma?
Pathophysiology
- Inflammatory mechanisms of asthma exacerbations
- Virus induction of neurogenic inflammation and airway responsiveness
- Antiviral immunity and protection against asthma exacerbations
- Lessons from RSV bronchiolitis and acute wheezing episodes in infants
- Virus induction of steroid resistance
In-vitro Experimental Models of Asthma Exacerbations
- In vitro models of bronchial epithelial cell infection
- In vitro models of macrophage infection
In-vivo Experimental Models of Asthma Exacerbations
- Murine models of allergen exposure and virus infection
- A murine model of rhinovirus infection
- A human experimental model of asthma exacerbation induced by rhinovirus infection
- Lessons from human experimental rhinovirus infection in combination with allergen exposure
Treatment & Prevention of Asthma Exacerbations
- Role of established asthma therapies in treating acute asthma exacerbations (adults and children)
- Role of leukotriene antagonists in the treating acute asthma exacerbations
- How good are inhaled steroids alone at preventing asthma exacerbations? (prophylactic and doubling dose)
- How good are inhaled steroids/LABA in combination at preventing asthma exacerbations?
- New targets for treatment/prevention of asthma exacerbations
Delivery of Care
- Role of self-management in preventing asthma exacerbations
- Psychosocial factors in severe asthma
- Sebastian L. Johnston, Imperial College London, England, UK
- Paul O'Byrne, McMaster University, Hamilton, Ontario, Canada
“With contributions from 38 renowned asthma experts, the editors provide a global view of asthma and its impact on morbidity and mortality. [...] I would recommend its purchase. [...] a well-referenced book that deals with a broad list of asthma topics. Overall the writing is clear, thorough, and well-organized. The content is timely and accurate.”
Respiratory Care
Respiratory Care
