Part I: Influence of Sleep and Respiration on the Cardiovascular System

• Circadian variations in clock genes: implications for cardiovascular disease
• Lower brainstem mechanisms of cardiorespiratory integration
• Mechanical interactions between the respiratory and circulatory systems
• Alterations in respiratory and cardiac activity during sleep onset
• Physiological effects of sleep on the cardiovascular system
• Metabolic effects of normal and disturbed sleep
• Oxidative stress, inflammation, and vascular function in sleep apnea
• Obesity, leptin and sleep apnea

Part II: Sleep Apnea and Hypertension

• Influence of sleep apnea on heart rate and blood pressure regulation: implications for hypertension and impaired heart rate variability
• Epidemiological evidence for an association between sleep apnea, hypertension and cardiovascular disease
• Treatment of hypertension in sleep apnea

Part III: Sleep Apnea, Ischemic Heart Disease, and Cerebrovascular Disease

• Cardiac arrhythmias and sleep apnea
• Sleep apnea and atherosclerosis
• Sleep apnea and cerebrovascular disease
• Circadian variation in the incidence of cardiovascular and cerebrovascular ischemic events

Part IV: Sleep Apnea and Congestive Heart Failure

• Theoretical models of periodic breathing
• Pathophysiological interactions between sleep apnea and congestive heart failure
• Prevalence and prognostic significance of obstructive and central sleep apnea in heart failure
• Treatment of obstructive and central sleep apnea in patients with heart failure

T. Douglas Bradley
Professor of Medicine and Director of the Centre for Sleep Medicine and Circadian Biology at the University of Toronto, the Cardiopulmonary Sleep Disorders and Research Centre at the Toronto General Hospital/University Health Network, and the Sleep Research Laboratory at the Toronto Rehabilitation Institute, Toronto, Canada. He has published over 140 papers and book chapters on sleep apnea and related topics. He is Member of the American Society for Clinical Investigation, Associate Editor of the American Journal of Respiratory and Critical Care Medicine, and is on the editorial board of SLEEP.

John S. Floras
Senior Scientist for the Division of Clinical Investigation and Human Physiology, Toronto General Research Institute, and for the University Health Network and Mount Sinai Hospital, Toronto, Canada. He is also Canada Research Chair in Integrative Cardiovascular Biology, and Career Investigator, Heart and Stroke Foundation of Ontario.

...."an important book to have available for training programs of sleep medicine, pulmonary and critical care, neurology, and cardiology programs"

Sleep Breath Journal