This new Third Edition presents an integrated approach to neurotoxicology, the study of organisms’ responses to changes in their environment and how interruption of the flow of information by chemical exposure causes a wide range of effects – from learning deficits, sensory disturbances in the extremities, and muscle weakness to seizures and signs similar to neurodegenerative disorders such as Parkinson’s or Alzheimer’s disease.
It is an essential resource for understanding the sites and mechanisms of neurotoxicity, for formulating testable hypotheses about the effects of neurotoxicants, and for improving the risk assessment process.
Molecular Approaches to Identify Specific Modes of Action for Neurotoxicity- in vitro
Bioinformatic and Computational Approaches for Analysis of Genomics Data in Neurotoxicology Research
Neurotoxicology of Barriers in the Developing Brain
Thyroid Hormones – Impact on the Developing Brain: Possible Mechanisms of Neurotoxicity
Dopaminergic Nerves as Targets for Neurotoxins
Endocrine Disruption and Senescence: Consequences for Reproductive Endocrine and Neuroendocrine Systems, Behavioral Responses and Immune Function
White Fat Tissue, Obesity, and Possible Role in Neurodegeneration
Microglia: Neuroprotective and Neurodestructive Properties
The Slice Culture Model: Considerations for Neurotoxicity Assessment
Design-Based Stereology and Video Densitometry For Assessment of Neurotoxicological Damage
Effect of Neurotoxins on Brain Tissue and Function Revealed Through in vivo MR Imaging and Spectroscopy
Principles of Behavioral Phenotyping of Neonatal and Adult Mice
G. Jean Harry National Institute of Environmental Health, Research Triangle Park, North Carolina, USA
Hugh A. Tilson US Environmental Protection Agency, Durham, North Carolina, USA
