PART 1: Principles of Toxicology

• Harming and Helping through Time: The History of Toxicology
• The Use of Toxicology in the Regulatory Process
• Metabolism: A Determinant of Toxicity
• Toxicokinetics
• Physiologically Based Pharmacokinetic and Toxicokinetic Models
• Toxicopanomics: Applications of Genomics, Proteomics, and Metabonomics in Predictive and Mechanistic Toxicology
• The Toxicologic Assessment of Pharmaceutical and Biotechnology Products
• Statistics for Toxicologists
• Quantitative Extrapolations in Toxicology
• The Practice of Exposure Assessment
• Epidemiology for Toxicologists
• Principles of Pathology for Toxicology Studies
• The Information Infrastructure of Toxicology

PART 2: Agents

• Foodborne Toxicants
• Solvents and Industrial Hygiene
• Crop Protection Chemicals: Mechanism of Action and Hazard Profiles
• Metals
• Ionizing Radiation
• Plant and Animal Toxins

PART 3: Methods

• The Use of Laboratory Animals in Toxicology Research
• Validation and Regulatory Acceptance of New, Revised, and Alternative Toxicological Methods
• Acute Toxicity and Eye Irritancy
• Genetic Toxicology
• Short-Term, Subchronic, and Chronic Toxicology Studies
• Principles of Testing for Carcinogenic Activity
• Principles of Clinical Pathology for Toxicology Studies
• Dermatotoxicology
• Inhalation Toxicology
• Detection and Evaluation of Chemically Induced Liver Injury
• Principles and Methods for Renal Toxicology
• Gastrointestinal Toxicology
• Principles and Methods of Cardiac Toxicology
• Assessment of Male Reproductive Toxicity
• Test Methods for Assessing Female Reproductive and Developmental Toxicology
• Hormone Assays and Endocrine Function
• Immunotoxicology: Effects of and Response to Drugs and Chemicals
• Assessment of Behavioral Toxicity
• Application of Isolated Organ Perfusion Techniques in Toxicology
• Organelles as Tools in Toxicology
• Analysis and Characterization of Enzymes and Nucleic Acids
• Modern Instrumental Methods for Studying Mechanisms of Toxicology
• Methods in Environmental Toxicology
• Glossary
• Index

A. Wallace Hayes:

A toxicologist with over 30 years of experience. He has written over 200 peer reviewed publications and is the editor of the textbook, Principles and Methods of Toxicology, the international Journal of Human and Experimental Toxicology and a co-editor of the Target Organ Toxicity Series. Dr. Hayes also is the editor of the Journal of Toxicology-Cutaneous and Ocular Toxicology. Before joining Harvard School of Public Health as a visiting scientist, Dr. Hayes was Vice President of Corporate Product Integrity at the Gillette Company, where he had management responsibility for the safety evaluation of a variety of consumer products, plant safety, environmental stewardship, and quality control.

Dr. Hayes is an adjunct professor at Wake Forest University School of Medicine, the University of Louisville School of Medicine and the School of Public Health, The University of Massachusetts. Dr. Hayes holds degrees from Auburn University (PhD in biochemistry, M.S. in physiology) and Emory University. Dr. Hayes was a NSF predoctoral fellow at Auburn University, a NIH postdoctoral fellow at the Vanderbilt University School of Medicine, and a NATO Senior Scientist at the Central Veterinary Laboratory, Weybridge, England. Dr. Hayes currently lectures at the Harvard School of Public Health and at Virginia Polytechnic and State University and in the Risk Assessment Summer School of the International Union of Toxicology. Dr. Hayes has served the International Union of Toxicology as the editor of the Proceedings of ICT III (Developments in the Science and Practice of Toxicology) and as the editor of the Proceedings of the 5th Congress of Toxicology in Developing Countries (Toxicology in New Century-Opportunity and Challenge).

Dr. Hayes has served as a delegate to IUTOX and on several IUTOX committees. In addition, Dr. Hayes has served on committees for the National Academy of Sciences, the National Institution of Health, and the Department of Defence. Dr. Hayes is a diplomat of the American Board of Toxicology, The Academy of Toxicology Sciences, the American Board of Forensic Medicine and the American Board of Forensic Examiners. He is a Fellow of the Academy of Toxicological Sciences and Institute of Biological Sciences (UK). Dr. Hayes is a registered toxicologist in the European Union (EUROTOX).

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