Part I: Skin Morphology and Barrier Properties
1. Structure and function of skin
2. Barrier function of skin
3. Skin lipids for barrier function
4. Tight junctions: a new barrier in the skin?
5. Basic principles involved in quantifying the dermal absorption of topically applied chemicals
6. Chemical structure-skin transport relationships
7. Cutaneous metabolism and active transport in transdermal drug delivery
8. Epidermal transporters and metabolism during dermal absorption: importance for toxicity
9. Hair follicle delivery
Part II: Altered Barriers
10. Structural and functional correlations of skin barrier in health and disease: models and evaluation
11. Are there differences in stratum structure & function in different racial skin types?
12. Skin absorption through a comprised skin barrier
13. The stratum corneum in aged and photo-aged skin
14. Cosmetics and skin barrier integrity
15. Sensing the environment
16. Skin Sensitization
17. Diseases associated with cutaneous barrier dysfunction: Basic science aspects, clinical perspectives
18. Skin surfactant proteins: presence & potential defense functions
Part III: Methods of Delivery
19. Liposomes as promising tools for the skin delivery & protection of damaged skin
20. Applications of microneedle technology to transdermal drug delivery
21. Active transdermal drug delivery
Part IV: Skin Toxicity
22. Nanomaterial penetration
23. Potential arsenic exposure through dermal penetration
24. Dermal absorption and cutaneous toxicity of metalworking fluids
25. Cutaneous bromine exposure: An overview and insight into post-exposure molecular responses
26. Effects of dermal exposure to jet fuel
27. Sulfur mustard toxicity
1. Structure and function of skin
2. Barrier function of skin
3. Skin lipids for barrier function
4. Tight junctions: a new barrier in the skin?
5. Basic principles involved in quantifying the dermal absorption of topically applied chemicals
6. Chemical structure-skin transport relationships
7. Cutaneous metabolism and active transport in transdermal drug delivery
8. Epidermal transporters and metabolism during dermal absorption: importance for toxicity
9. Hair follicle delivery
Part II: Altered Barriers
10. Structural and functional correlations of skin barrier in health and disease: models and evaluation
11. Are there differences in stratum structure & function in different racial skin types?
12. Skin absorption through a comprised skin barrier
13. The stratum corneum in aged and photo-aged skin
14. Cosmetics and skin barrier integrity
15. Sensing the environment
16. Skin Sensitization
17. Diseases associated with cutaneous barrier dysfunction: Basic science aspects, clinical perspectives
18. Skin surfactant proteins: presence & potential defense functions
Part III: Methods of Delivery
19. Liposomes as promising tools for the skin delivery & protection of damaged skin
20. Applications of microneedle technology to transdermal drug delivery
21. Active transdermal drug delivery
Part IV: Skin Toxicity
22. Nanomaterial penetration
23. Potential arsenic exposure through dermal penetration
24. Dermal absorption and cutaneous toxicity of metalworking fluids
25. Cutaneous bromine exposure: An overview and insight into post-exposure molecular responses
26. Effects of dermal exposure to jet fuel
27. Sulfur mustard toxicity
"...this book is a worthy addition to the Target Organ Toxicology Series. Reading this book has added to my knowledge of toxicity resulting from skin exposure and given me a greater appreciation of key factors, which should be taken into consideration when assessing risk from chemicals which come into contact with the skin... I would not hesitate to recommend it to anyone working in the regulatory field, as a general easy to read general quick reference book." - The British Toxicology Society Newsletter
